Abstract: Active faults can trigger strong earthquakes, cause engineeringbreak, creep deformation, and induce geological disasters, which seriously threaten the planning, construction and operate safely of major projects. In this study, based on the statistics of co-seismic surface ruptures, the avoidance distances of faults with different properties and the ranges of extremely strong, strong, moderately strong and moderately affected areas of active fault zones are established. According to the remote sensing, geological survey, dislocation landform and shallow seismic exploration, the avoidance distance and affected range of the Litang fault on the Tibetan Plateau were analyzed. The Litang fault is mainly characterized by strike slip with normal fault components, The hanging wall avoidance distance is 30m and the footwall wall avoidance distance is 15m. The extremely strong, moderately strong, strong and moderately affected areas of the Litang fault zones are 0-150m, 200-500m, 500-1000m and 1000-3000m, respectively. The research results can provide basic data for the planning and construct of major projects and national land space control.