Abstract: Fault systems in the Central uplift of the Dongying depression are complex. The fault sealing properties directly control the formation and distribution of the oil/gas accumulation as well as its size and type. Large oil/gas accumulations may form near a fault with good sealing properties, while small accumulations or even no accumulations occur near a fault with poor sealing properties. Take for example the lithological combination seal model, principal stress seal model and shale smear zone seal model, a fault seal model is established and fault sealing properties are quantitatively analyzed and evaluated in the Central uplift of the Dongying depression. The optimal normal stress of the sealing fault in the study area is about 40 to 50 MPa and the shale smear factors for the sealing fault is commonly <2.6. To judge whether a particular fault has sealing properties requires an integrated analysis, and one must not make single-factor analysis simply.