Abstract: According to the recent survey evaluation and integrated study of mineral resources in South China, this paper summaries the characteristics of structural control of ore deposition at different spatial lev els, from the lithosphere to microfracture networks, including deep lithosphere delamination and thinning and related geodynamic regime transition of tectono-metallogonic domains →control of distribution of metallogenic belts (ore concentration areas) by regional tectonic thinning zones and related alkali-rick (A-type) mogma assoications →control of distribution of small (porphyry) rock bodies and related ore fields (deposits) by structural compounding loci →control of occurrence of orebodies by major faults and their associated and derivative fracture networks →control of concentration of ore substances by dynamic transition of structure deformation and related hydrofracturing.It put special emphasis on the dominant role that tensile structural systems of different scales related to mesozoic lithospheric delamination play in controlling ore deposition.This has great significance for the metallogenic analysis and mineral exploration.